AssayLink

Template catalogue

Every assay definition, including drafts and templates under review.

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Assay type

cocktail inhibition assay2clearance assay1hepatocyte induction assay1

Experimental setting

✓ in vitro4

Assay format

✓ cell-based4

Detection type

UPLC-MS/MS4qPCR1

Target

CYP1A23CYP3A43CYP1A12CYP2C192CYP2C82CYP2C92CYP2D62

Expected readout

AUCR2✓ CLint1Emax1✓ Fmax1fold induction1NOEL1✓ t1/21

1 template matching your filters

ADME / DMPK

Metabolism, clearance, drug–drug interaction, permeability, transport and protein binding.

1
  • PK Hep CL

    PK-HEP-CL · v1 · Dr Amelia Ostrowski

    Published

    Assessment of metabolic stability and calculation of intrinsic clearance (CLint) and bioavailability (Fmax) in hepatocytes.

    clearance assayhepatic enzymesUPLC-MS/MSt1/2CLintFmax