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Every assay definition, including drafts and templates under review.

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Assay type

cocktail inhibition assay2clearance assay1hepatocyte induction assay1

Experimental setting

in vitro4

Assay format

✓ cell-based4

Detection type

UPLC-MS/MS4✓ qPCR1

Target

CYP1A23CYP3A43CYP1A12CYP2C192CYP2C82CYP2C92CYP2D62

Expected readout

AUCR2CLint1✓ Emax1Fmax1✓ fold induction1NOEL1t1/21

1 template matching your filters

ADME / DMPK

Metabolism, clearance, drug–drug interaction, permeability, transport and protein binding.

1
  • PK Induction in Heps

    PK-IND-HEPS · v1 · Dr Amelia Ostrowski

    Published

    Assessment of a test compound's potential to induce the expression and activity of CYP1A2 and CYP3A4 enzymes.

    hepatocyte induction assayCYP1A2CYP3A4qPCRUPLC-MS/MSfold inductionEmaxNOEL